Takeda Nears Deal to Buy Shire in Its Biggest Purchase

  • Shire seeks increase in cash component of 46 billion-pound bid
  • Drugmakers could announce agreement as early as Tuesday

Takeda Ramps Up Takeover Ambitions

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Takeda Pharmaceutical Co. is nearing an agreement to buy rival drugmaker Shire Plc, people familiar with the matter said, in what would mark the biggest ever takeover by the Japanese company.

A deal agreement could be announced as early as Tuesday, the deadline set by U.K. regulators for Takeda to make a firm offer for Shire, according to the people, who asked not to be identified because the information is private.